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Journal Club Date Articles Topic
October 2018 Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. N Engl J Med. 2018 Oct 18;379(16):1519-1528. doi: 10.1056/NEJMoa1803955. primary prevention Join #GeriMedJC on Oct 19 at 08:00ET
October 2018 Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. JAMA Surg. 2018 Aug 8. [Epub ahead of print] delirium Join #GeriMedJC on Oct 19 at 08:00ET
September 28 2018 Estimation of lifetime risks of Alzheimer’s disease dementia using biomarkers for preclinical disease. Alzheimers Dement. 2018 Aug;14(8):981-988.  PMID: 29802030  dementia  YouTube archive
 August 2018 Use of haloperidol versus atypical antipsychotics and risk of in-hospital death in patients with acute myocardial infarction: cohort study. BMJ 2018;360:k1218  antipsychotics  YouTube archive
 August 2018 Acetylcholinesterase inhibitors and risk of stroke and death in people with dementia. Alzheimers Dement. 2018 Jul;14(7):944-951.  dementia  YouTube archive
July 2018 Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ 2018;361:k1675 dementia YouTube archive
July 2018 Antipsychotic Deprescription for Older Adults in Long-term Care: The HALT Study. J Am Med Dir Assoc. 2018 Jul;19(7):592-600.e7. PMID: 29941156 BPSD YouTube archive
May 2018 Medicaid Cost Savings of a Preventive Home Visit Program for Disabled Older Adults. J Am Geriatr Soc. 2018 Mar;66(3):614-620. PMID: 29165789 home visits YouTube archive
May 2018 Evaluation of the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer’s disease psychosis: a phase 2, randomised, placebo-controlled, double-blind study. Lancet Neurol. 2018 Mar;17(3):213-222. PMID: 29452684 dementia YouTube archive
April 2018 Impact of Age on Pain Perception for Typical Painful Diagnoses in the Emergency Department. J Emerg Med. 2016 Jan;50(1):14-20. PMID:26416133 pain  YouTube archive
April 2018  Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer’s disease pathophysiology (SNAP) or Alzheimer’s disease pathology: a longitudinal study. Lancet Neurol 2016; 15: 1044–53. PMID:27450471 cognitive impairment  YouTube archive
April 2018  Age and gender variations of sleep in subjects without sleep disorders. Annals of Medicine, 2015; 47: 482–491. PMID:26224201 sleep  YouTube archive
March 2018 Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized double-blind phase 2 study. Neurology. 2018 Feb 20;90(8):e664-e672. PMID:29367449 parkinsonism YouTube archive
February 2018 DHA supplementation improves cognitive function via enhancing Aβ-mediated autophagy in Chinese elderly with mild cognitive impairment: a randomised placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2017 Nov 15. PMID: 29142143 cognition  YouTube archive
February 2018 Association Between Purpose in Life and Objective Measures of Physical Function in Older Adults. JAMA Psychiatry. 2017 Oct 1;74(10):1039-1045. PMID: 28813554 physical function YouTube archive
January 2018 Methylphenidate for Apathy in Community-Dwelling Older Veterans With Mild Alzheimer’s Disease: A Double-Blind, Randomized, Placebo-Controlled Trial. Am J Psychiatry. 2017 [Epub ahead of print] PMID: 28945120 BPSD Youtube archive
January 2018 Personal Sound Amplification Products vs a Conventional Hearing Aid for Speech Understanding in Noise. JAMA. 2017 Jul 4;318(1):89-90. PMID: 28672306 hearing Youtube archive
December 2017 Reliable adherence to a COPD care bundle mitigates system-level failures and reduces COPD readmissions: a system redesign using improvement science. BMJ Qual Saf. 2017 Nov;26(11):908-918.  PMID: 28733370 improvement science
November 2017 Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc. 2017 Aug;65(8):1705-1711. PMID: 28306154 mobility
October 2017 Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis. N Engl J Med. 2017 Oct 12;377(15):1417-1427. PMID: 28892457 osteoporosis
September 2017 Association of a Communication Training Program With Use of Antipsychotics in Nursing Homes. JAMA Intern Med. 2017 Jun 1;177(6):846-853. PMID: 28418449 dementia
September 2017 Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. J Am Geriatr Soc. 2017 Sep;65(9):1988-1995. PMID: 28653345 sarcopenia
Associations of acetylcholinesterase inhibitor treatment with reduced mortality in Alzheimer’s disease: a retrospective survival analysis. Age Ageing. 2017 Jun 24:1-7. PMID: 28655175 dementia
August 2017 Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med. 2017 May 18;376(20):1943-1955. PMID: 28514618 frailty Download transcript
July 2017 Medical Directive for Urinary Catheter Removal by Nurses on General Medical Wards. PMID: 26571234 continence Download transcript
July 2017 Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial. JAMA Surg. 2017 [ahead of print] PMID: 28538964 delirium Download transcript
May 2017 Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. N Engl J Med. 2017  [Epub ahead of print] PMID: 28402245 hypothyroidism Download transcript
March 2017 What paint can tell us: A fractal analysis of neurological changes in seven artists. Neuropsychology. 2017 Jan;31(1):1-10. PMID: 28026197 neurodegenerative disorders Download transcript
March 2017 Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial. JAMA. 2016 Aug 16;316(7):722-33.  PMID: 27533157script osteoporosis Download transcript
February 2017 Effects of Testosterone Treatment in Older Men. N Engl J Med. 2016 Feb 18;374(7):611-24. PMID:26886521 Testosterone Download transcript
January 2017 The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature. 2016 Sep 1;537(7618):50-6. PMID: 27582220 Dementia Download transcript
November 2016 Effectiveness of medication withdrawal in older fallers: results from the Improving Medication Prescribing to reduce Risk Of FALLs (IMPROveFALL) trial. Age Ageing. 2016 Sep 10. PMID: 27614080  Falls Download transcript
November 2016 Elder-Clowning in Long-Term Dementia Care: Results of a Pilot Study. J Am Geriatr Soc. 2016 Feb;64(2):347-53. PMID: 26889843  Dementia Download transcript
October 2016 Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med. 2010 Oct 21;363(17):1597-607. PMID: 20961243  Aortic stenosis Download transcript
October 2016 Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet. 2016 Oct 15;388(10054):1893-1902. PMID: 27542303 Delirium Download transcript
September 2016 Effectiveness of two year balance training programme on prevention of fall induced injuries in at risk women aged 75-85 living in community: Ossébo randomised controlled trial. BMJ. 2015 Jul 22;351:h3830.
PMID: 26201510
Falls Download transcript
August 2016 Comparison of Posthospitalization Function and Community Mobility in Hospital Mobility Program and Usual Care Patients: A Randomized Clinical Trial. JAMA Intern Med. 2016 Jul 1;176(7):921-7. PMID: 27243899 Functional decline Download transcript
August 2016 Fascia iliaca block prophylaxis for hip fracture patients at risk for delirium: a randomized placebo-controlled study.
J Orthop Traumatol. 2009 Sep;10(3):127-33. PMID: 2744739
Hip fracture


Download transcript
July 2016 Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo-controlled trial. PMID: 25677354 Depression Download transcript
July 2016 Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults. JAMA Neurol. 2016 [ahead of print].
PMID: 27088965
Cognitive impairment Download transcript
April 2016 Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2016 [Epub ahead of print]. PMID: 26997557  Osteoarthritis Download transcript
March 2016 Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb 1;176(2):175-83.  PMID: 26747333 Functional decline Download transcript
March 2016 Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial.Lancet. 2016 Jan 12.  [Epub ahead of print]. PMID: 26794722 Cardiac disease Download transcript
February 2016 A Randomized, Controlled Trial of Total Knee Replacement. N Engl J Med. 2015 Oct 22;373(17):1597-606. PMID: 26488691 Osteoarthritis Download transcript
February 2016 Comprehensive geriatric assessment on an acute medical unit: A qualitative study of older people’s and informal carer’s perspectives of the care and treatment received. Clin Rehabil. 2016 Jan 22. [Epub ahead of print] PMID: 26801585 CGA Download transcript
January 2016  A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. PMID: 26551272 Hypertension Download transcript
January 2016 Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. Am J Med. 2015 Nov;128(11):1225-1236. PMID: 26159634  Frailty Download transcript
December 2015  Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning-the DANTE Study Leiden: A Randomized Clinical Trial. JAMA Intern Med. 2015 Oct 1;175(10):1622-30. PMID: 26301603 Cognitive Impairment Download transcript
December 2015 Practical problems with medication use that older people experience: a qualitative study. J Am Geriatr Soc. 2014 Dec;62(12):2339-44. PMID: 25516030 Polypharmacy Download transcript
November 2015 Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29;314(12):1242-54. PMID: 26393847 Dementia Download transcript
October 2015 Medical students’ and doctors’ attitudes towards older patients and their care in hospital settings: a conceptualisation. Age Ageing. 2015 Sep;44(5):776-83. PMID: 26185282 Medical Education Download transcript

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October 2015 Comprehensive geriatric care for patients with hip fractures: a prospective, randomised, controlled trial. Lancet. 2015 Apr 25;385(9978):1623-33. PMID:25662415 Hip Fracture Download transcript

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September 2015 Effects of low blood pressure in cognitively impaired elderly patients treated with antihypertensive drugs. JAMA Intern Med. 2015 Apr;175(4):57885. PMID:25730775 Cognitive Impairment Download transcript

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August 2015 Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015 May 28;372(22):2087-96. PMID: 25916341 Herpes Zoster Download transcript
August 2015 Delayed-start analysis: Mild Alzheimer’s disease patients in solanezumab trials, 3.5 years. Alzheimer’s & Dementia: Translational Research & Clinical Interventions. 2015; 111-121. Link Dementia Download transcript
July 2015 Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med. 2015 May;175(5):691-700. PMID: 25798575 Polypharmacy Download transcript
July 2015 A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015 Jun 6;385(9984):2255-63.PMID: 25771249 Cognitive Impairment Download transcript
May 2015 Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015 Apr 1;175(4):494-501. PMID: 25686304 Sleep Download transcript
May 2015 Risk factors and screening instruments to predict adverse outcomes for undifferentiated older emergency department patients: a systematic review and meta-analysis. Acad Emerg Med. 2015 Jan;22(1):1-21. PMID: 25565487 Geriatric Emergency Download transcript
April 2015 Nonpharmacologic management of orthostatic hypotension: a systematic review. Arch Phys Med Rehabil. 2015 Feb;96(2):366-375. PMID: 25449193 Orthostatic Hypotension Download transcript
March 2015 American Geriatrics Society abstracted clinical practice guideline for postoperative delirium in older adults. J Am Geriatr Soc. 2015 Jan;63(1):142-50. PMID: 25495432 Delirium Download transcript
March 2015 Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014 Jul 22;83(4):328-35. PMID: 24944260 Orthostatic Hypotension Download transcript
February 2015 Home modifications to reduce injuries from falls in the Home Injury Prevention Intervention (HIPI) study: a cluster-randomised controlled trial. The Lancet, Volume 385, Issue 9964, 17–23 January 2015, Pages 231-238. PMID: 25255696 Falls Download transcript
January 2015 Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial. JAMA Psychiatry. 2015 Jan 1;72(1):22-30. PMID: 25372657 Depression Download transcript
January 2015


Fracture prediction after discontinuation of 4 to 5 years of alendronate therapy: the FLEX study. JAMA Intern Med. 2014 Jul;174(7):1126-34. PMID: 24798675 Osteoporosis Download transcript
December 2014 Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis. Age Ageing. 2014 Jul;43(4):464-71. PMID: 24895018 Hip Fracture Download transcript
December 2014 Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial. J Am Geriatr Soc. 2014 Sep;62(9):1658-65. PMID: 25243680 Polypharmacy Download transcript
November 2014 3D-CAM: Derivation and Validation of a 3-Minute Diagnostic Interview for CAM-Defined Delirium: A Cross-sectional Diagnostic Test Study. Ann Intern Med. 2014 Oct 21;161(8):554-61. PMID: 25329203 Delirium Download transcript
November 2014 Osteoporotic Fractures in Men Study Group. Implications of expanding indications for drug treatment to prevent fracture in older men in United States: cross sectional and longitudinal analysis of prospective cohort study. BMJ. 2014 Jul 3;349:g4120. PMID: 24994809 Osteoporosis Download transcript
October 2014 Effect of melatonin on incidence of delirium among patients with hip fracture: a multicentre, double-blind randomized controlled trial. CMAJ. 2014 Oct 7;186(14):E547-56. PMID: 25183726 Delirium, Hip Fracture Download transcript
October 2014 Effect of Physical Therapy on Pain and Function in Patients With Hip Osteoarthritis. A Randomized Clinical Trial JAMA. 2014;311(19):1987-1997.PMID: 24846036 Physiotherapy, Osteoarthritis Download transcript
September 2014 Atypical Antipsychotic Drugs and the Risk for Acute Kidney Injury and Other Adverse Outcomes in Older Adults.  Ann Intern Med.2014;161:242-248. PMID: 25133360 Antipsychotics Download transcript
September 2014 The efficacy and tolerability of the b3-adrenoceptor agonist Mirabegron for the treatment of symptoms of overactive bladder in older patients. Age and Ageing 2014;43:666–675. PMID: 24610862 Incontinence Download transcript
August 2014 The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med. 2014 Apr 15;160(8):526-33. PMID: 24733193 Delirium Download transcript
August 2014 Multidimensional Frailty Score for the Prediction of Postoperative Mortality Risk. JAMA Surg. 2014;149(7):633-640. PMID: 24804971 Frailty Download transcript


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